First life birth after trans­plan­ta­tion of ova­rian tissue removed and frozen during child­hood. A young woman has become the first in the world to give birth to a healthy child after doc­tors res­tored her fer­ti­lity by trans­plan­ting ova­rian tissue that had be removed and frozen while she was a child. A report of the case is published in Human Repro­duc­tion. While there have been reports of suc­cessful pregnan­cies after ova­rian trans­plan­ta­tion using tissue that had been removed from pati­ents when they were adults, there have been none using tissue taken from girls before puberty and the ability of such imma­ture ova­rian tissue to develop to pro­duce mature eggs is unclear.